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Aplastic anemia
Aplastic
anemia, aplastic anemia short. Department of multiple causes of red bone marrow
of capacity reduction, hematopoietic failure, and pancytopenia as the main
performance of a group syndrome. For anemia, bleeding and infection as the main
clinical manifestations. These cases of acute severe symptoms. Chronic cases
are relatively common (about 80%), to the slow onset, mainly anemia, fatigue,
heart palpitations, dizziness, looking pale infections, infections, fever and
bleeding less. Acupuncture treatment for the main target. The disease of
unknown etiology, with chemistry, physics, infection, immune factors and
genetic factors and so on.
Acupuncture treatment of aplastic anemia modern
reported that about occurred in the 1960s, early in the case based more. Until
the 1970s, the clinical observation of cases continued to increase. Through
more than 20 years of work, acupuncture treatment for the disease has been the
law must recognize : acupuncture main targets are slow
Sexual aplastic anemia patients, not only to adults, children have the same
effect. Treatment usually in the conventional drug therapy on the basis of more
comprehensive acupoint stimulation, such as the combination of acupuncture and
moxibustion, or acupuncture with drug inje
Electroacupuncture
Points
Main Points : Dazhui.
Points allocation : divided into 2 groups. 1, Shenshu,
Zusanli; 2, Gaohuang, Hegu, Xuehai.
Aplastic
anemia
This somewhat misleading term is applied to pancytopenia
characterized by (1) anemia (2) neutropenia and (3) thrombocytopenia.
Thebasis for these changes is a failure or suppression of multipotent myeloid stem cells, with in adequate production or release of the
differentiated cell lines
Most cases of aplastic anemia of so-called known etiology
follow exposure to chemicals and drugs. With some agents the marrow damage is predictable,
dose related and in most instances reversible when the use of the offending
agent is stopped . Best documented as known myelotoxins are benzene,
chloramphenicol, alkylating agents and antimetabolites. In most cases the
pancytopenia appears as an apparent idiosyncratic reaction to very small doeses
of known myelotoxins (e.g., chloramphenicol) or after the use of such drugs as
phenybutazone, methylphenylethylhydantion , steptomycin and chlorpromazine,
which are generally without effect in other individuals. In such idiosyncratic
reactions the aplasia may be severe and sometimes irreversible and fatal.
Whole body irradiation is an obvious mechanism for
destruction of hematopoietic stem cells. The effects of ratdiation are dose
related . Persons at risk are those who receive therapeutic irradiation and
individuals exposed to nuclear explosions or nuclear plant accidents.
Although aplastic anemia may appear after a
variety of infections , it most commonly follows viral hepatitis of the non – A , non-B, non-C, non-g type.
Why certain individuals develop this hematologic complicationin the course of
their infection is not understood but it is not related to the severity of
infection.
Fanconi anemia is a rare autosomal recessive disorder
characterized by defects in DNA repair. In these patients the marrow
hypofunction becomes evident early in life and is accompanied by multiple
congenital anomalies, such as hypoplasia of the kidney and spleen and hypoplasstic anamalies of bone,
particularly involving the thumbs or radii.
Despite all these possible causal influences no provocative
factor can be identified in fully 65% of the cases and hence they are lumped
into the idiopathic category.
The pathogenesis of aplastic anemia is not fully understood. Indeed it is
unlikely that a single mechanism underlies all cases of marrow aplasia. Two
major mechanisma have been invoked an immunologically mediated suppression and
an intrinsic abnormality of stem cells.
Recent studies suggest that in a large proportion of cases
perhaps in as many as 70% marrow failure results from inhibition of stem cell
proliferation and differentiation by activated T cells. It is postulated that
at first the stem cells are antigenially alteredby exposure to drugs,
infectious agents or other undentified environmental insults. This then evokes
a T cell-mediated immune rsponse during which cytokines such interferon ?and
TNF-? are produced by activated T cells. These cytokines are known to be potent
inhibitors of stem cell function. This scenario is supported by activated T
cells. These cytokines
are non to be potent inhibitors of stem cells function. This scenario is
supported by the observation that immunosuppressive therapy with anthymocyte
globulin combined with drugs such as cyclosporine has a salutary effect in 60^
to 70% of patients.
The notion that aplastic anemia results from a fundamental
stem cell abnormality is supported by studies that indicate that in may cases
of aplastic anemia cells in the peripheral blood are clonal descendants of a
single stem cell. Some forms of marrow insult presumably cause genetic damage
that results in the generation of stem cell with poor proliferative and
differentitative capacity. If one such altered stem cell dominates the
resultant picture that of aplastic anemia. The occasional transformation of
aplastic anemia into acute leukemia lends further credence to this hypothesis.
These two mechanisms are not mutually exclusive. The genetically altered stem
cells not only may have poor proliferative capacity but also may be
antigenically altered thus inducing a secondary T cell mediated suppression.
Clinical Course
Aplastic anemia may occur at any age. The onset is uaually
gradual but in some cases the disorder strikes with suddenness and great
severity. The initial manifestations vary somewhat , depending on the cell line
predominantly affected. Anemia may cause the progressive onset of seakness
pallor and dyspnea. Petechiae and ecchymoses may herald thrombocytopenia.
Granulocytopenia may manifest itself only by frequent and persistent minor
infections or by the sudden onset of chills, fever and prostration. Splenomegaly
is characteristically absent and if it is present the diagnosis of aplastic
anemia should seriously questioned. The red cells are typically normocytic and
normochromic although slight macrocytosis is occasionally present
reticulocytosis is absent.
Chinese Chang Gung Memorial Hospital did a research about this,their
conclusion is :Our study implied that acupuncture might be beneficial in the
management of neurogenic bladder of SCI, and the earlier the patient received
electro-acupuncture therapy, the sooner the bladder balanced. On the other hand,
we also found that complete spinal cord injury, either with
pronounced detrusor-sphincter dyssynergia in upper motor neuron lesion or with
persistent areflexic bladder in lower motor neuron-lesion, was not affected by
acupuncture.
So,you have to had right diagnosis,otherwise ,,,,,,
Although conventional non-pharmacological and pharmacological treatments for
insomnia are effective in many people, alternative therapies such as acupuncture
are still widely practiced. However, it remains unclear whether the existing
evidence is rigorous enough to support its use. basically,Acupuncture therapy is
effective on dementia according to the domestic clinical literatures. However,
the quality of the studies needs further improving and increasing(1).
So,Acupuncture is not miracle,you have to think about it.I just don't
understand why so many people claim acupuncture can help many/any
things.... ____________________________________________________________ (1)
Zhongguo Zhen Jiu. 2008 Feb;28(2):140-4
Later research:There is no evidence from randomized controlled trials to
determine whether acupuncture provides any effect when treating people with
vascular dementia
Another research:Scalp electroacupuncture or scalp electroacupuncture
combined with oral administration of Nimodipine has a better therapeutic effect
in improvement of recognition function and the ability of life activity than
simple oral administration of Nimodipine with a higher safety.
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